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Similarly, impeding the CYFIP1/Rac1 interaction or the CYFIP1/NCKAP1 dimer formation, could have a dual beneficial effect in concomitantly restoring normal levels of protein synthesis and actin dynamics, both processes being dysregulated in FXS

Both outcomes are due to the absence of NF-B target genes, as represented as the JNK pathway-inhibiting molecules GADD45 and XIAP 19,20 , and the antioxidant proteins manganese superoxide dismutase (MnSOD) and ferritin heavy chain 21,22

Can J Physiol Pharmacol 54:92636 Rights and permissions About this article Cite this article Burstein, R., Hourvitz, A., Epstein, Y

Biochem J 189: 373376 Chen Z, Young TE, Ling J, Chang SC, Gallie DR (2003) Increasing vitamin C content of plants through enhanced ascorbate recycling