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Does long-term use of proton pump inhibitors cause vitamin B 12 deficiency

2017 Jun;6(6):2222-2225 Kulshreshtha B, Pahuja I, Kothari D, Chawla I, Sharma N, Gupta S, Mittal A

Glucagon receptors are highly concentrated not only in the liver, which is the preferred site for T3 action, but also in adipose tissues, kidney, and the cardiovascular system resulting in metabolic enhancement along with toxicity risk