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For example, conventional chondrogenic factors (Jonitz et al., 2012), epigenetic manipulation with specific agents (Duan et al., 2017), or co-culture with mesenchymal stem cells (Lai et al., 2013), have been shown to promote or maintain chondrocytic phenotype

These are mechanisms observed primarily in animal and cell-culture models, and they remain an active area of investigation rather than settled clinical fact

Though our study benefited from the large sample size permitted by 100% Medicare claims data, such administrative claims databases do not permit an accurate examination of the incidence of common antipsychotic adverse effects (e.g., anticholinergic effects, weight gain, insomnia) and how they impacted treatment discontinuation and psychiatric hospitalization

Retatrutide is more aggressive mechanistically

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