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Additionally, apigenin suppresses the mTOR/PI3K/AKT signaling pathway, thereby promoting autophagy in erythroid subtype leukemia (TF-1), liver cancer (Hep G2), and colon cancer (HT-29) cells [67,68,69,70]

Initially, generally lower doses are prescribed, such as sertraline 25mg or 50mg, that may gradually be titrated upward based on the patients response and tolerance