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As discussed above, unlike Y37 rAmy , P37 Cagri does not interact directly with RAMP1 or RAMP3, which likely decreases the stability of the ECD interface, leading to increased dynamics relative to the rAmy-bound AMY 1 R and rAmy-bound AMY 3 R (Fig

Its anti-inflammatory properties (reducing TNF-alpha-induced IL-6 secretion in fibroblasts) and wound-healing activity make it a useful companion for skin that is adjusting to retinoids

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