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Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics

But you should always inform your healthcare provider about all medications and supplements you're using

48 The regulation of XBP1s can govern the redox balance by modulating the expression of antioxidant enzymes

Many spin traps react relatively ineffectively with superoxide (e.g., PBN has weak in vitro antioxidant activity), so high doses are required to achieve a therapeutic benefit