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A study comparing individuals with insomnia to healthy sleepers found significantly lower glutathione peroxidase activity in the insomnia group

Notably, 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, is elevated in liver biopsy specimens of MASLD patients, and 31 P-MRS imaging has demonstrated ATP depletion consistent with mitochondrial dysfunction [101, 102]

This design concept aligns closely with recent reports of multifunctional nanosystems developed for tumor and immunotherapy applications

For example, DMOCPTL regulates EGR1 in TNBC cells and induces GPX4 ubiquitination to reduce EGR4 protein levels, thereby regulating mitochondria-mediated apoptosis [80]