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161,162 Amitriptyline is a tricyclic antidepressant that raises serotonin and norepinephrine availability by inhibiting their reuptake

Athira Pharma's fosgonimeton (ATH-1017), part of the same HGF/c-Met program, failed the primary endpoint of its Phase 2/3 LIFT-AD Alzheimer's trial in September 2024