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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

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Similarly, a controlled clinical investigation evaluated the effects of CBATO-TACE ( n = 38) on arsenic trioxide/lipiodol emulsions (standard TACE) ( n = 48) in patients with unresectable HCC

During the initial trimester of pregnancy, fetal mitochondria exhibit a degree of immaturity and reduced expression of OCTs, suggesting that the administration of metformin in the first trimester is associated with a relatively low-risk profile

Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches