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DMF Antioxidant Activity Dimethyl fumarate (DMF) is considered a prodrug as, after oral administration, it is rapidly hydrolyzed by esterases in the small intestine and converted to MMF (Figure 1)

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The first dose administered outside of a clinical trial in the United States was given to Sandra Lindsay on 14 December 2020

1.7.2 Short- and long-term exposures In repeated dose studies, by both the oral and inhalation routes, toxic effects at relatively low concentrations were limited principally to the sites of initial contact