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UA activates the inflammatory response of tissue-intrinsic cells indirectly affecting immune cells MSU crystals activate the TLR4/NF-B/NLRP3 signaling pathway in human umbilical vein endothelial cells (HUVECs), leading to the secretion of intercellular cell adhesion molecule-1 (ICAM-1), IL-1, IL-6, and vascular cellular adhesion molecule-1 (VCAM-1)

Bulletin Du Cancer 107:629632 Huang FL, Liao EC, Li CL, Yen CY, Yu SJ (2020) Pathogenesis of pediatric B-cell acute lymphoblastic leukemia: molecular pathways and disease treatments

Full blood and reticulocyte count: Within 7 to 10 days of starting treatment and then after 8 weeks of treatment Iron and folate level (if not done already): After 8 weeks of treatment Neurological symptoms: Improvement begins within one week and complete resolution usually occurs between six weeks and three months

The Elements of Statistical Learning: Data Mining, Inference, and Prediction (Springer, New York, NY, USA, 2009), 2nd edn