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Metformin reduces endothelial injury by increasing insulin sensitivity and scavenging free radicals [164] , while TZDs such as rosiglitazone activate the PPAR- pathway, exert anti-inflammatory effects, and improve vascular responsiveness [165]

This approach can introduce bias, as lifetime abstainers may avoid alcohol due to pre-existing health conditions 17,18 , and former drinkers may have stopped drinking due to illness 19,20

Metallomics 7, 14591476

A novel significance score for gene selection and ranking