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Copper has been reported to have a partial bactericidal effect in the treatment of septicemia (Yan et al., 2024), thus it is possible to speculate that sepsis promotes cuproptosis in skeletal muscle cells, inducing SAW

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Aberrant redox homeostasis and elevated ROS levels in the TME have historically made ROS elimination an attractive therapeutic strategy

Clin Cancer Res 29(21):44304440 Ji C, Yang B, Yang YL, He SH, Miao DS, He L, Bi ZG (2010) Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition