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Notch signaling is also elevated in human bone during aging, 226 and loss of Notch signaling increases the number of skeletal stem and progenitor cells and improves the skeletal aging phenotype

Infection, inflammation or liver disease can elevate serum ferritin levels, complicating measurements in individuals with these conditions

It also acts as an excitatory neurotransmitter and plays a significant role in the sleep-wake cycle

In addition, it is commonly included in experimental models designed to explore metabolic responses and signalling behaviour