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Herein, we did not identify studies that correlated effort-related motivational aspects, such as those assessed by the Effort-Based Decision-Making and Learned Helplessness tests, in animal models of anxiety or depression subjected to exposure to caffeine and related xanthines, while also evaluating inflammatory parameters

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In the future, by integrating AI-driven closed-loop neuromodulation, multi-target drug intervention, and neuro-microbiome precision strategies, the spatiotemporal signal network of 7nAChR and the multi-transmitter synergistic mechanism can be analyzed to achieve individualized neuro-immune treatment for diseases such as sepsis

When the mixing time is increased even more, the magnetization moves to 1 H D , and correlation signal D appeared