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Cell 124 : 471484 Xie Y et al

Real-world experience with tofacitinib in IBD at a tertiary center

P., Perez-Garcia, F

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These combined modifications reduce IGF-1 LR3's binding affinity for IGFBPs by approximately 100-1000 fold compared to native IGF-1, meaning that a much higher proportion of IGF-1 LR3 exists in the free, bioactive state capable of directly engaging IGF-1 receptors on target cells