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110 JankeR.DodsonA

NLRP3 Inflammasome at the Interface of inflammation, endothelial dysfunction, and type 2 diabetes

doi: 10.1089/bfm.2021.0082 16 JulioCWandersonKORodrigoLFLuizHMDjaneCBSJosDBSet al

Mechanisms of Protection: Upregulation of superoxide dismutase (SOD) and catalase key antioxidant enzymes Suppression of pro-inflammatory cytokine production (IL-6, TNF-) Activation of cellular repair pathways (autophagy, protein synthesis) Restoration of wound-healing fibroblast function Clinical Evidence & Research Applications Skin Regeneration & Photoaging Topical GHK-Cu has been investigated in multiple clinical trials examining its effects on sun-damaged skin (photoaging), wrinkles, skin thickness, and elasticity