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Thermal denaturation of DNA in situ as studied by acridine orange staining and automated cytofluorometry

259 In addition, the simultaneous knockout of HDAC3, HDAC5, and HDAC7 (class I and class II HDACs) resulted in the CDKN1A (p21) upregulation and inhibition of cell proliferation, 260 similar to p21 induction and cell cycle arrest in human mesenchymal stem cells after drug-induced inhibition of HDAC activity

1 Introduction Osteoporosis is a common skeletal condition marked by a decrease in bone mass and the degradation of the microstructure of bone tissue, resulting in increased fragility of bones and an elevated likelihood of fractures ( In recent times, ferroptosis, an innovative type of cellular demise, has attracted considerable interest within the domain of bone metabolism