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Tianma modulates (ER-resident) molecular chaperone proteins in differentiated neuronal N2a cells Skp1a : Decreased expressions of the ubiquitin-proteasome/E3 ligase component Skp1a and the chaperone Hsc-70 can lead to a wide impairment in the function of an entire repertoire of proteins in neurons [60] suggesting a new structural role of Skp1a in dopaminergic neuronal functions besides its E3 ligase activity [61]

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10.1016/j.theriogenology.2020.10.009 70 YangL.WangH.SongS.XuH.ChenY.TianS.et al (2022)

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