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While not listed as a direct adverse effect in FDA prescribing information, this cold sensitivity appears linked to the medication's weight loss effects rather than direct temperature regulation changes

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( A , B ) Myocardial infarction (one isoprenaline challenge) and re-infarction (two isopre- naline subsequent challenges) in isoprenaline-treated rats (75 mg/kg sc (gray bars), 150 mg/kg sc (white bars))

Total spot polarization improved in both groups, and total skin tone improvement was slightly greater in the glutathione supplement group than in the placebo group, although this difference did not reach statistical significance