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Considering these features, AgNPs are utilized in melanoma prevention, diagnosis, and treatment, with a focus on PDT, photothermal therapy, and chemotherapy [177]

This sophisticated crosstalk, where parallel pro-apoptotic pathways (ATF4-driven induction and CHOP-mediated fine-tuning) converge on the CHAC1 promoter, allows for precise control of cell fate under prolonged ER stress (Nomura et al., 2020)