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22, 23 In children with GHD, changes were identified in MAPK- and GRB2/SOS-mediated signaling pathways (e.g., IGF-I) associated with carriage of the A allele ( GRB2 decreased expression 1.2-fold, SOS1 increased expression +1.2-fold)

Thus, the study personnel were blinded to group allocation

Step 2: Vital signs are assessed, and the procedure is explained thoroughly

BMC Cell Biol 16:2 Voon LW, See J, Wong TY (2001) The epidemiology of ocular trauma in Singapore: perspective from the emergency service of a large tertiary hospital