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These metabolites translocate across the compromised ruminal epithelial barrier into the systemic circulation, reaching the liver via the portal vein and subsequently triggering multiple injury mechanisms, as previously described 170

(2006) Biochemistry 45 : 3852-3862 PubMed: 16548513 Search on PubMed DOI: Primary Citation Related Structures: 1XW6, 1XWK, 2F3M PubMed Abstract: An active site His107 residue distinguishes human glutathione S-transferase hGSTM1-1 from other mammalian Mu-class GSTs

For example, the lysosome has emerged as a key signalling hub enabling activation of crucial autophagy regulators such as mTORC1 (ref

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