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First, one important issue is how to accurately detect sKlotho in serum or body fluid

On one hand, it functions as an intrinsic tumor-suppressive mechanism, eliminating early-stage tumor cells or those under specific stresses

The epidural space is the space between the outermost covering of the spinal cord (dura mater) and the wall of the spinal canal

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Upon stimulation by cytokines, stress signals, or pathogens, IBs are degraded, allowing NF-B to translocate into the nucleus, where it binds DNA and regulates the expression of genes involved in inflammation, immunity, and apoptosis