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Melanocortin agonists include PT-141 and Melanotan II, while mitochondrial and longevity peptides include MOTS-C and Epithalon

So, perhaps the function of the ergothioneine transporter at the blood-brain barrier declines with age, potentially making mushroom intake all the more beneficial as we grow older

Corrales A, Martnez P, Garca S, Vidal V, Garca E, Flrez J, Sanchez-Barcel EJ, Martnez-Cu C, Rueda N (2013) Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome