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Gait impairments in Parkinsons disease

Chronic manganese exposure is known to cause progressive neurological damage with PD-like symptoms (Pajarillo et al., 2022)

transgenic mouse models

The pathogenesis of tau-mediated neurodegeneration is unclear, but hyperphosphorylation, oligomerization, fibrillization, and propagation of tau pathology have been proposed as the likely pathological processes that induce the loss of function or gain of tau toxicity, which cause neurodegeneration