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INTERACTION OF MELATONIN WITH REACTIVE OXYGEN (ROS), NITROGEN (RNS) AND CHLORIDE SPECIES (RCIS) As mentioned before, melatonin synthesis in pineal gland and at extrapineal sites, depends upon two enzymes that are recognized to play an essential role in this biosynthesis, namely, AA-NAT and HIOMT (see Fig

These efforts must be combined with the generation of in vivo and in vitro models to validate molecular targets identified from omics analyses of marine-species