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The mechanism diagram was created with BioRender.com

Collectively, these observations establish that NRF2 alone can sustain sufficient transcriptional output to maintain cancer cell line growth and that metabolic reprogramming of cells driven by NRF2 does not require redox buffering via enhanced glutathione production

If you see elevated levels of glutathione on your oxidative stress test, then NAD and glutathione may indeed push one into a Reductive Stress pattern and it is best to avoid these antioxidants