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Cancer Cell 22 , 547560 (2012)

Applying techniques such as ChIP-chip, ChIP-Seq, ChIP-exo and CUT&RUN, and bioinformatics tools, the work of multiple groups has defined the genome-wide landscape of AR binding sites in CaP cell lines and tissues, which has allowed to more closely examine and characterize the corresponding DNA sequences [53]

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MMA needs to be diagnosed by laboratory methods, and relatively high concentrations of methylmalonic acid and methyl citrate in patient urine, as determined by GC/MS, can lead to a definitive diagnosis of the disorder

Other studies have confirmed that OS can reduce the ovarian follicle stimulating hormone (FSH) activity by downregulating the expression of the FSH regulatory gene P450 aromatase and then decreasing the expression of FSHR (9,10)