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Although our study mainly focused on the protective role of MeCbl in inhibiting GSDME-mediated liver failure, it is important to note that GSDME is universally expressed in diverse other organs and may represent a key executor in mediating multiple pyroptotic organ damage

Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, et al

Impact on blood vessels: Effects on blood vessel function and tone can contribute to clot formation

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