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The free energy released from the hydrolysis of phosphocreatine to creatine + Pi is used as a buffer in the resynthesis of ATP

We next performed in vitro PARylation reactions using purified recombinant RSMC and PARP1

Therefore, the model could be improved by considering activity changes in drug metabolism in obese patients, and the amount of glycogen stored in the liver may need to be adjusted for obese patients