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Although vitamin C is a vitamin that the body needs, it cannot be produced in the body

Tumors can also hijack DC maturation to decrease MHC expression and destroy the costimulatory machinery by secreting suppressive factors such as TGF-, interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF) [110]

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In the TME, competition for glutamine between tumor cells and myeloid cell SLC1A5 transporters significantly promotes MDSC generation and recruitment, while inhibiting the formation of anti-tumor inflammatory TAMs, thus impairing anti-tumor immunity (79)

The NAC Breakdown: Although oral NAC is slightly more resistant to stomach acid than glutathione, its oral bioavailability is still considered very poor (often less than 10%), meaning your liver breaks down most of it before it can reach the rest of your body