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A slightly more expensive product with verified purity may offer better long-term value than a cheaper alternative with unknown composition

A lack of B12 can lead to tiredness, poor concentration, and, in more serious cases, nerve damage

Importantly, there were no cardiovascular adverse events, no clinically significant changes in blood pressure or heart rate, no alterations in thyroid function, no immunogenicity with no anti-AOD-9604 antibodies detected, and no signs of tolerance or receptor desensitization

Response: We thank commenters for their feedback and the request for clarification

Figure 1 illustrates typical energy use in an ice arena