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However, when the levels of Ca 2+ in the mitochondrial matrix are high, especially during oxidative stress, as often observed in ASD patients, mPTP remains open for a longer time

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Afterward, the mitochondrial suspensions were centrifuged at 2000 g for 20 min

5.3 Genetic therapies 5.3.1 Antisense oligonucleotide (ASO) targeted therapy: from gene expression correction to multi-target interventions Antisense oligonucleotides (ASOs) are precision gene regulatory tools that, via base complementary pairing, target cellular RNA to achieve high-specificity modulation of key post-transcriptional processes

Its important to note that while complementary therapies like acupuncture and massage can be beneficial, they should be used in conjunction with conventional medical treatment or natural remedies rather than as a standalone solution