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Given that EMT-related transcription factors can be triggered by phosphorylation [37], previous studies have shown that ion channels can affect signal transduction by modulating the phosphorylation homeostasis [38,39,40]

A larger study by the Hanson group employed machine learning to distinguish ME/CFS patients from healthy controls with 79.1% accuracy (AUROC value 0.891) using only seven proteins (Giloteaux et al., 2023)