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Nicol, Edith

3 Mechanisms of drug resistance driven by tumor heterogeneity Tumor heterogeneity enables therapeutic resistance through interconnected genetic, epigenetic, phenotypic, and microenvironmental mechanisms that coexist within tumors and interact, as summarized in Table 1 and Figure 1 , to generate drug-tolerant subpopulations that enable early resistance, underscoring the need for molecularly resolved, evolution-aware treatment strategies

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This work was supported by the Theme-based Research Scheme (T12-712/21-R), RGC Hong Kong SAR Government, Hong Kong SAR, China

Through a series of optimization, we developed RT that enables quantitative real-time imaging of GSH in living cells