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Consequently, leucine increases rapidly in circulation after meal [22], and are readily available as an essential nutritional signal to reduce food intake via mTOR-dependent inhibition of hypothalamic Agouti-related protein ( Agrp ) gene expression [23, 24]

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Previous study demonstrated that curcumin protected human blood lymphocytes cells from negative side effects such as lipid peroxidation and DNA damage that occurred with the administration of mitomycin C (an antitumor agent) [276]