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However, glutathione deficiency has been strongly associated with loss of function with aging and the onset of diseases

Research suggests it helps balance the immune response and may reduce biomarkers like C-reactive protein, though liposomal delivery is often required for meaningful absorption

Expert Rev Mol Med 17:e6

Therefore, ferroptosis inducers include compounds that inhibit system Xc - (erastin, imidazole ketone erastin (IKE), sulfasalazine) 7,9 , compounds that directly inhibit GPX4 (RSL3, ML-210) 8 , and compounds that inhibit glutathione synthesis (buthionine sulfoximine) 8

In the current study, the lowest levels of Pb found in the gills, as contrasting to the liver, may be ascribed to the reduced binding affinity of Pb on the gill surface