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Hyperactivity in the PAG, thalamus, ACC, and somatosensory cortex might be one of the final common pathways to symptoms of CIPN, as these brain regions support interoception (Kleckner et al., 2017), the processing and perception of sensations from the body (Khalsa et al., 2018)

Int J Androl 1984;7:484-94

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Mens Health 33 , 143160 (2015)