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Conclusion: We demonstrate through multiple lines of evidence that the LPAR/PI3K/AKT axis is vital for the activation of YAP and hepatic fibrogenesis due to HIV infection

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Unlike other cell death modalities, paraptosis lacks the typical apoptotic hallmarks, such as DNA condensation, DNA breakage, membrane blistering, and apoptotic bodies

For example, the dual effect of sericin on osteoblasts and osteoclasts has been shown in rodents [9], but clinical studies are needed to confirm the efficacy and safety of sericin as an osteoporosis or bone-healing treatment in humans

These include areas of potential bias such as whether studies used blinding and control groups, and if the study methodology was explicit