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The most common cause of intrinsic DILI is APAP overdose mechanistically through mitochondrial dysfunction and hepatocyte damage [4], and the severity of idiosyncratic DILI varies based on the geographical region of prevalence [264] and environmental factors such as alcohol consumption and other pathological conditions, including obesity, insulin resistance, and (pre)diabetes

Current treatments for AR include allergen avoidance, immunotherapy, and drug therapy

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There is evidence that endogenous oxalate synthesis may be heightened in MASLD leading to increased urinary oxalate excretion

However, it is unknown whether the entity of these alterations is associated with the severity of DD