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Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet

However, due to the low affinity of H 2 O 2 to the SOD1 active site, non-physiologically high concentrations of H 2 O 2 (1020 mM) were required to produce substantial amounts of HO 92 , questioning the significance of this reaction to ALS pathogenesis