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Description

& Yu, B

This article describes 67 patients who developed hepatic injury after ingestion of acetaminophen for therapeutic reasons

At the transcriptional level, this treatment coincides with the modulated expression of genes encoding chromatin remodeling complexes (e.g., SWI/SNF, SNF2) and transcription factors (e.g., WRKY, NAC, bZIP)

Results may be influenced by: Changes over time are often easier to interpret when testing is performed through the same laboratory and under similar fasting, medication, exercise, and collection conditions

Higher doses can stall the same process or even tip into toxicity over longer exposures, where free copper drifting loose from the complex starts driving oxidative damage