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Acknowledgements This research was supported by the Air Force Office of Scientific Research Grants AFOSR FA2386-20-1-4060, NIH 5R01DK133864, NIH R01AG084098 and by the National Research Foundation of Korea (RS-20210NR061784)

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PDRN (Polydeoxyribonucleotide): the adenosine A2A receptor agonist PDRN is a mixture of short and long DNA polymers extracted, in commercial preparations, from the gametes of salmon trout