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Oxidative stress, inflammation and accelerated ageing are accompanied by damage to the central nervous system, including neurodegeneration

A principal transcription factor, NRF2, which stimulates the expression of a broad set of genes that act towards the restoration of redox balance and reduce the damage from ROS, in a large part regulates the response to oxidative stress (230, 231)

Extrarenal mechanism include potassium uptake by both liver and muscle generally, and intestinal secretion of potassium

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Process of preparation of transdermal composition of claim 2 comprising i) Dissolving preformed GHK-Cu complex in water to form drug phase