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Successful activation of immune therapy recruits CD8 T cells to the tumor site, enhancing tumor cell ferroptosis via IFN-related pathways, representing a significant advancement in efficient tumor eradication strategies

129 Specially, studies also found that IDH1 is significantly downregulated in clear cell renal cell carcinoma (ccRCC) compared with normal kidney cells, suggesting that IDH1 may function as a candidate tumor suppressor for ccRCC

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