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This promotes Nrf2 nuclear translocation and ARE binding, upregulating antioxidant enzymes such as Superoxide Dismutase 1(SOD1), Heme Oxygenase-1(HO-1), and Glutathione Peroxidase (GPx) (Wang et al., 2020

Single-cell RNA sequencing data have shown that some genes expressed in mouse islets are differentially expressed or completely undetected in human islets and vice versa (200)