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Other potential challenges include anatomical barriers of the anterior eye that limit glutathione delivery to the lens and intracellular barriers within the lens that limit glutathione delivery to different lens regions

doi: 10.1016/J.BCP.2010.01.010

Amy Yasko ( talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12: COMT V158M VDR Taq B12 Types That Should Be Tolerated + + (TT) All 3 types of B12 + (Tt) All 3 types of B12 with less Methylcobalamin (tt) Hydroxy B12 and Adenosylcobalamin + + + All 3 types of B12 with less Methylcobalamin + + Hydroxy B12 and Adenosylcobalamin + Hydroxy B12 and Adenosylcobalamin + + + + Hydroxy B12 and Adenosylcobalamin + + + Hydroxy B12 and Adenosylcobalamin + + Mostly Hydroxy B12