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For example, the severity of skin lesions in psoriasis patients is associated with the levels of systemic inflammatory markers and increases the risk of cardiovascular disease, suggesting that skin inflammation can serve as an important mediating factor for systemic inflammation ( in vitro model of photoaging, it was found that the addition of silymarin preparation further increased the phosphorylation level of p-Smad2/3 and enhanced the deposition of collagen (especially type XVII) and elastin

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doi:10.1016/j.drudis.2019.03.021 94