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Gastroenterology (2017) 153(2):4209

The first vaccine an individual receives induces a strong primary immune response that shapes responses to subsequent infection and vaccination, an effect known as imprinting, said senior author Michael S

coli , the target protein was purified using a Ni-NTA column (Thermo Fisher Scientific, MA, USA)

To this end, the development of new therapies, ideally targeting synovitis and inflammatory-related bone erosion in joints, as well as regulating those inflammation-independent factors that can also interfere with bone homeostasis in RA, such as the general RANKL signaling pathway, would be promising for remodeling bone homeostasis in RA